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Both agents block the aldosterone receptor, however, spironolactone has progestogenic and antiandrogenic actions, effects which are minimized in eplerenone. Thus far, the incidence of adverse effects with eplerenone was slightly lower than with spironolactone. Study selection and data extraction: Research and review articles related to eplerenone, aldosterone, aldosterone antagonist, and spironolactone were reviewed. Animal studies with eplerenone have shown a favorable function for aldosterone antagonism in treating hypertension, heart failure, myocardial infarction, renal dysfunction, and atherosclerosis. Conclusions: Eplerenone is apparently a promising drug in a new class of agents called selective aldosterone blockers. The drug may qualify for treatment of hypertension in 2002. Further studies are continuing that will offer advice on other clinical applications for this medicine. In people, eplerenone seems to be successful for treating hypertension.
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